The researchers found the relation between Cancer and DNA. The group of researchers found the patient reporting strange tumour cells with glioblastoma, a highly aggressive form of brain Cancer. The genomic sequencing group tumours displayed a specific growth-promoting oncogene. The drug was given to the patients but they showed no improvement.
The tumours were removed surgically and researchers noticed the number of copies of the targeted epidermal growth factor receptor gene, probably giving them the advantage to escape the drugs, and they had evolved these genetic differences at a rate. The cancers are evolving over many cell divisions, as the cells carrying genetic changes that provide a fitness advantage. That provides an ability to resist a particular treatment that will survive and divide.
The circular nature of the can allow the gene interactions that may support the increased transcription of oncogenes, as genetic elements normally found in distant parts of the genome may come together to interact. While additional regulatory sequences sit at the stem of a loop structure and ensure that regulatory sequences such as enhancers work only on their nearby target genes, the circular shape of extrachromosomal generates new interactions with additional regulatory sequences that would not normally occur on chromosomal DNA.